Back to Search
Start Over
Characteristics of lung cancer after a previous malignancy.
- Source :
-
Respiratory medicine [Respir Med] 2014 Jun; Vol. 108 (6), pp. 910-7. Date of Electronic Publication: 2014 Mar 05. - Publication Year :
- 2014
-
Abstract
- Background: In the era of improving overall survival rates of malignant diseases, the impact of a previous malignancy (PM) on treatment and outcome of lung cancer (LC) remains unclear.<br />Methods: We reviewed all LC patients from our institution that were treated from 2004 to 2006 for the occurrence of LC with PM excluding patients with multiple primary LC.<br />Results: A total of 444 and 2698 LC patients with and without a history of a PM were identified (prevalence of 14.1%). PM were most often located in breast (15.5%), prostate (14.9%), bladder (9.0%) and kidney (8.8%). Compared to never smokers, patients with nicotine consumption had more often a cancer history of prostate, gastrointestinal, and the head-neck region. The median interval until diagnosis of LC was 72.2 months (range 0-537 months) with most LC diagnosed 5 years after PM diagnosis. With a similar distribution of histology, stage and localization compared to controls, NSCLC patients with PM and stage IV disease showed a favorable overall survival (p < 0.0001). In contrast, SCLC patients had similar survival curves (n.s.).<br />Conclusions: A considerable subgroup of LC patients has a history of PM that may indicate a favorable prognostic factor. However, these patients should be treated similar to other LC patients.<br /> (Copyright © 2014 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adult
Age Distribution
Aged
Aged, 80 and over
Carcinoma, Non-Small-Cell Lung therapy
Case-Control Studies
Female
Germany epidemiology
Humans
Lung Neoplasms therapy
Male
Middle Aged
Neoplasms, Second Primary therapy
Prevalence
Prognosis
Sex Distribution
Small Cell Lung Carcinoma therapy
Carcinoma, Non-Small-Cell Lung mortality
Lung Neoplasms mortality
Neoplasms, Second Primary mortality
Small Cell Lung Carcinoma mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1532-3064
- Volume :
- 108
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Respiratory medicine
- Publication Type :
- Academic Journal
- Accession number :
- 24650574
- Full Text :
- https://doi.org/10.1016/j.rmed.2014.02.015