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Case control study of the factor V Leiden and factor II G20210A mutation frequency in women with recurrent pregnancy loss.
- Source :
-
Iranian journal of reproductive medicine [Iran J Reprod Med] 2013 Jan; Vol. 11 (1), pp. 61-4. - Publication Year :
- 2013
-
Abstract
- Background: Recurrent pregnancy loss (RPL) caused by various genetic and non-genetic factors. After chromosome abnormality, thrombophilia is one of the most important genetic factors that could cause RPL. Factor V Leiden and factor II G20210A mutation were the most common mutations cause thrombophilia in the world.<br />Objective: The purpose of this study was to determine the frequency of factor V Leiden and prothrombine gene mutations in women with RPL compared with women who had uneventful pregnancies.<br />Materials and Methods: This case control study evaluates the frequency of factor V-Leiden and factor II G20210 genotypes in 80 women with two or more pregnancy losses, compared with 80 women without adverse pregnancy outcome. The mutations were assessed by PCR-RFLP.<br />Results: Frequency of the factor V Leiden among cases was 2.5%, which was higher than controls (1.25%), but the difference was not significant. No factor II G20210 mutation was found among cases and controls.<br />Conclusion: These data did not confirm that factor V Leiden and factor II G20210 mutation might play a role in recurrent pregnancy loss in Iranian women.
Details
- Language :
- English
- ISSN :
- 1680-6433
- Volume :
- 11
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Iranian journal of reproductive medicine
- Publication Type :
- Academic Journal
- Accession number :
- 24639694