Back to Search
Start Over
Productive dual infection of human CD4+ T lymphocytes by HIV-1 and HHV-6.
- Source :
-
Nature [Nature] 1989 Jan 26; Vol. 337 (6205), pp. 370-3. - Publication Year :
- 1989
-
Abstract
- Although infection by HIV-1 has been implicated as the primary cause of AIDS and related disorders, cofactorial mechanisms may be involved in the pathogenesis of the disease. For example, several viruses commonly detected in AIDS patients and capable of transactivating the long terminal repeat of HIV-1, such as herpesviruses, papovaviruses, adenoviruses and HTLV-I have been suggested as potential cofactors. Another candidate is human herpesvirus-6 (HHV-6, originally designated human B-lymphotropic virus), which has not only been identified in most patients with AIDS by virus isolation, DNA amplification techniques and serological analysis, but is also predominantly tropic and cytopathic in vitro for CD4+ T lymphocytes. Here we demonstrate that HHV-6 and HIV-1 can productively co-infect individual human CD4+ T lymphocytes, resulting in accelerated HIV-1 expression and cellular death. We also present evidence that HHV-6 transactivates the HIV-1 long terminal repeat (LTR). These observations indicate that HHV-6 might contribute directly or indirectly to the depletion of CD4+ T cells in AIDS.
- Subjects :
- Cells, Cultured
HIV-1 genetics
HIV-1 physiology
Humans
Kinetics
Microscopy, Electron
RNA, Messenger analysis
RNA-Directed DNA Polymerase metabolism
Receptors, HIV
Simplexvirus genetics
Simplexvirus physiology
T-Lymphocytes microbiology
T-Lymphocytes ultrastructure
HIV-1 immunology
Receptors, Virus immunology
Simplexvirus immunology
T-Lymphocytes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0028-0836
- Volume :
- 337
- Issue :
- 6205
- Database :
- MEDLINE
- Journal :
- Nature
- Publication Type :
- Academic Journal
- Accession number :
- 2463490
- Full Text :
- https://doi.org/10.1038/337370a0