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Neonatal experience interacts with adult social stress to alter acute and chronic Theiler's virus infection.
- Source :
-
Brain, behavior, and immunity [Brain Behav Immun] 2014 Aug; Vol. 40, pp. 110-20. Date of Electronic Publication: 2014 Mar 12. - Publication Year :
- 2014
-
Abstract
- Previous research has shown that neonatal handling has prolonged protective effects associated with stress resilience and aging, yet little is known about its effect on stress-induced modulation of infectious disease. We have previously demonstrated that social disruption stress exacerbates the acute and chronic phases of the disease when applied prior to Theiler's virus infection (PRE-SDR) whereas it attenuates disease severity when applied concurrently with infection (CON-SDR). Here, we asked whether neonatal handling would protect adult mice from the detrimental effects of PRE-SDR and attenuate the protective effects of CON-SDR on Theiler's virus infection. As expected, handling alone decreased IL-6 and corticosterone levels, protected the non-stressed adult mice from motor impairment throughout infection and reduced antibodies to myelin components (PLP, MBP) during the autoimmune phase of disease. In contrast, neonatal handling X PRE/CON-SDR elevated IL-6 and reduced corticosterone as well as increased motor impairment during the acute phase of the infection. Neonatal handling X PRE/CON-SDR continued to exacerbate motor impairment during the chronic phase, whereas only neonatal handling X PRE-SDR increased in antibodies to PLP, MOG, MBP and TMEV. Together, these results imply that while handling reduced the severity of later Theiler's virus infection in non-stressed mice, brief handling may not be protective when paired with later social stress.<br /> (Copyright © 2014 Elsevier Inc. All rights reserved.)
- Subjects :
- Acute Disease
Age Factors
Animals
Animals, Newborn
Chronic Disease
Interleukin-6 immunology
Male
Mice
Mice, Inbred BALB C
Motor Activity immunology
Myelin Proteins immunology
Cardiovirus Infections immunology
Handling, Psychological
Social Behavior
Stress, Psychological immunology
Theilovirus immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2139
- Volume :
- 40
- Database :
- MEDLINE
- Journal :
- Brain, behavior, and immunity
- Publication Type :
- Academic Journal
- Accession number :
- 24632225
- Full Text :
- https://doi.org/10.1016/j.bbi.2014.03.002