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Macrophages and fibrosis in adipose tissue are linked to liver damage and metabolic risk in obese children.
- Source :
-
Obesity (Silver Spring, Md.) [Obesity (Silver Spring)] 2014 Jun; Vol. 22 (6), pp. 1512-9. Date of Electronic Publication: 2014 Mar 08. - Publication Year :
- 2014
-
Abstract
- Objective: Obesity in childhood is associated with an inflammatory state in adipose tissue and liver, which elevates risk for diabetes and liver disease. No prior study has examined associations between pathologies occurring in adipose tissue and liver to identify elements of tissue damage associated with type 2 diabetes risk. This study sought to determine whether inflammation and fibrosis in abdominal subcutaneous adipose tissue (SAT) in obese/overweight children (BMI-z 2.3 ± 0.76) was related to the extent of observed liver disease or type 2 diabetes risk.<br />Methods: Biopsy samples of abdominal (SAT) and liver were simultaneously collected from 33 Italian children (mean BMI 28.1 ± 5.1 kg/m(2) and mean age 11.6 ± 2.2 years) with confirmed NAFLD. Histology and immunohistochemistry were conducted on biopsies to assess inflammation and fibrosis in adipose tissue and fibrosis and inflammation in liver.<br />Results: Presence vs. absence of crown-like structures (CLS) in SAT was significantly related to liver fibrosis scores (1.7 ± 0.7 vs. 1.2 ± 0.7, P = 0.04) independent of BMI. SAT fibrosis was significantly correlated with a lower disposition index (r = -0.48, P = 0.006). No other adipose measures were associated with liver disease parameters.<br />Conclusion: Markers of subcutaneous white adipose tissue inflammation are associated with greater extent of liver fibrosis independent of obesity and SAT fibrosis may contribute to diabetes risk through reduced insulin secretion.<br /> (Copyright © 2014 The Obesity Society.)
- Subjects :
- Adiponectin blood
Adiposity
Adolescent
Alanine Transaminase blood
Aspartate Aminotransferases blood
Biomarkers blood
Blood Glucose metabolism
Body Height
Body Mass Index
Body Weight
C-Reactive Protein metabolism
Child
Diabetes Mellitus, Type 2 complications
Diabetes Mellitus, Type 2 metabolism
Fasting
Female
Humans
Insulin blood
Interleukin-6 blood
Liver pathology
Liver Cirrhosis complications
Male
Obesity complications
Prospective Studies
Risk Factors
Tumor Necrosis Factor-alpha blood
Intra-Abdominal Fat pathology
Liver Cirrhosis pathology
Macrophages cytology
Obesity physiopathology
Subcutaneous Fat, Abdominal pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1930-739X
- Volume :
- 22
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Obesity (Silver Spring, Md.)
- Publication Type :
- Academic Journal
- Accession number :
- 24616207
- Full Text :
- https://doi.org/10.1002/oby.20730