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Patterns of natural killer cell function activation in response to interferon in chronic HBsAG positive hepatitis: relationship with the state of viral infection and with the early clinical response.
- Source :
-
Journal of biological regulators and homeostatic agents [J Biol Regul Homeost Agents] 1987 Jan-Mar; Vol. 1 (1), pp. 45-50. - Publication Year :
- 1987
-
Abstract
- In an effort to define immunobiological parameters identifying "responders" vs "non-responders" to IFN among hepatitis patients, 16 patients with chronic active hepatitis were screened for changes of Natural Killer cell activity (NK). 10/16 patients replicated the hepatitis B virus (HBV-DNA positive) whereas 6/16 replicated the defective B virus associated delta virus (HDV-RNA positive). Patients received 9 MU/3x/weekly/3 months of recombinant IFN alpha A. Mean NK activity of the HBV-DNA patients rose significantly from 29.9 +/- 5.3 to 45 +/- 4.7 during therapy, whereas the 6/16 HDV-RNA positive patients did not show any significant increase of NK activity. Interestingly, individual HDV-RNA positive patients exhibiting boosted NK activity also showed improvement of disease confirmed by clearance of intrahepatic delta antigen at one year. No such a correlation was found amongst the HBV-DNA positive patients. These data indicate that in spite of widespread individual variability, IFN-mediated NK boost may herald delta clearance and help in identifying "responders" and "non-responders" in IFN trials.
- Subjects :
- Adult
DNA genetics
Female
Hepatitis B therapy
Hepatitis B virus genetics
Hepatitis Delta Virus genetics
Hepatitis, Chronic physiopathology
Hepatitis, Chronic therapy
Humans
Interferons therapeutic use
Lymphocyte Activation
Male
Middle Aged
RNA genetics
Viral Interference
Hepatitis B physiopathology
Hepatitis B Surface Antigens immunology
Hepatitis, Chronic immunology
Interferons pharmacology
Killer Cells, Natural physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0393-974X
- Volume :
- 1
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of biological regulators and homeostatic agents
- Publication Type :
- Academic Journal
- Accession number :
- 2461050