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Insulin-like growth factor-I and -II levels are associated with the progression of nonalcoholic fatty liver disease in obese children.
- Source :
-
The Journal of pediatrics [J Pediatr] 2014 Jul; Vol. 165 (1), pp. 92-8. Date of Electronic Publication: 2014 Mar 05. - Publication Year :
- 2014
-
Abstract
- Objective: To correlate circulating levels of insulin-like growth factor (IGF)-I, IGF-II, and IGF binding protein (IGFBP)-3 in a population of obese children with biopsy-proven nonalcoholic fatty liver disease (NAFLD) with clinical, biochemical, and histological features.<br />Study Design: We conducted a cross-sectional study at the Hepatometabolic Unit of the Bambino Gesù Children's Hospital, Rome, Italy. Obese children (42 girls and 57 boys) underwent liver biopsy, anthropometry, biochemical assessment, and IGF system evaluation. Serum concentrations of IGF-I, IGF-II, and IGFBP-3 were measured. The liver biopsy features of each case were graded according to the NAFLD Activity Scoring system. The degrees of steatosis, inflammation, ballooning, and fibrosis were calculated.<br />Results: Nonalcoholic steatohepatitis was diagnosed in 14/99 obese subjects. Stepwise regression analysis revealed that IGF-I was the major predictor of ballooning (β = -0.463; P < .0001) and NAFLD activity score (β = -0.457; P < .0001), IGF-I/IGFBP-3 ratio was the major predictor of liver inflammation (β = -0.285; P = .005), and IGF-II was the major predictor of liver fibrosis (β = 0.343; P < .005).<br />Conclusion: Circulating levels of IGF-I and IGF-II are associated with the histological stages of NAFLD and may represent novel markers of liver damage progression in obese children.<br /> (Copyright © 2014 Elsevier Inc. All rights reserved.)
- Subjects :
- Biopsy
Child
Cross-Sectional Studies
Disease Progression
Fatty Liver metabolism
Female
Humans
Insulin-Like Growth Factor Binding Protein 3 blood
Liver pathology
Male
Non-alcoholic Fatty Liver Disease
Pediatric Obesity metabolism
Regression Analysis
Biomarkers blood
Fatty Liver diagnosis
Insulin-Like Growth Factor I metabolism
Insulin-Like Growth Factor II metabolism
Pediatric Obesity diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6833
- Volume :
- 165
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Journal of pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 24607243
- Full Text :
- https://doi.org/10.1016/j.jpeds.2014.01.052