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Selective and persistent deposition and gradual drainage of iodized oil, Lipiodol in the hepatocellular carcinoma after injection into the feeding hepatic artery.
- Source :
-
American journal of clinical pathology [Am J Clin Pathol] 1988 Nov; Vol. 90 (5), pp. 536-44. - Publication Year :
- 1988
-
Abstract
- The selective and long-term deposition of iodized oil in the hepatocellular carcinoma (HCC) and its gradual drainage were clinicopathologically analyzed in 13 cases. All patients were Japanese and had an intrahepatic arterial injection of Lipiodol (LIP) mixed with Mitomycin C. The comparison among the follow-up computerized tomography (CT) findings, the observation of the soft x-ray radiogram, and histopathologic studies of the surgical or autopsy materials revealed that the selective deposition of LIP in HCC lasted for a long term, particularly in cases treated by LIP combined with transcatheter arterial embolization (TAE). Also revealed was an extremely gradual decrease of LIP from the HCC. It was thus postulated that, mainly, the accumulated macrophages surrounding LIP around the necrotic cancer tissue and, partially, the intrahepatic lymphatic system itself contributed to this drainage. Further, in histologic sections with lipid staining, x-ray microanalysis proved that the lipid droplets in the cancer tissue included highly concentrated iodine, as a deposition of LIP.
- Subjects :
- Carcinoma, Hepatocellular diagnostic imaging
Carcinoma, Hepatocellular pathology
Electron Probe Microanalysis
Embolization, Therapeutic
Hepatic Artery
Humans
Injections, Intra-Arterial
Liver diagnostic imaging
Liver metabolism
Liver pathology
Liver Neoplasms diagnostic imaging
Liver Neoplasms pathology
Mitomycin
Mitomycins therapeutic use
Necrosis
Tissue Distribution
Tomography, X-Ray Computed
alpha-Fetoproteins blood
Carcinoma, Hepatocellular metabolism
Iodized Oil pharmacokinetics
Liver Neoplasms metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9173
- Volume :
- 90
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- American journal of clinical pathology
- Publication Type :
- Academic Journal
- Accession number :
- 2459957
- Full Text :
- https://doi.org/10.1093/ajcp/90.5.536