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Human epidermal growth factor receptor-2 positivity predicts locoregional recurrence in patients with T1-T2 breast cancer.
- Source :
-
Anticancer research [Anticancer Res] 2014 Mar; Vol. 34 (3), pp. 1207-12. - Publication Year :
- 2014
-
Abstract
- Aim: To determine the impact of biological subtypes defined by hormonal receptors and human epidermal growth factor receptor-2 status on risk of recurrence in women with invasive breast cancer treated with breast-conserving therapy.<br />Patients and Methods: Between 2001-2005, we observed 590 women with invasive breast cancer. They underwent conservative surgery, adjuvant radiotherapy and hormonotherapy or chemotherapy. None received adjuvant trastuzumab. The Kaplan-Meier method was applied to calculate for the 36-month and 60-month rates of locoregional recurrence-free survival and overall survival.<br />Results: The overall 36- and 60-month actuarial Kaplan-Meier survival rates were 98.5% and 97.7%, respectively; the locoregional recurrence-free survival rates were 95.2% and 91.2%, respectively. Locoregional recurrence rate was significantly greater in patients with human epidermal growth factor receptor-2 (15.2% vs. 5.3%, p<0.001).<br />Conclusions: Patients with hormone receptor-negative or human epidermal growth factor receptor-2-positive T1-T2 breast cancer seem to have a greater risk of disease recurrence.
- Subjects :
- Antineoplastic Combined Chemotherapy Protocols therapeutic use
Breast Neoplasms pathology
Breast Neoplasms therapy
Carcinoma, Ductal, Breast pathology
Carcinoma, Ductal, Breast therapy
Carcinoma, Intraductal, Noninfiltrating pathology
Carcinoma, Intraductal, Noninfiltrating therapy
Carcinoma, Lobular pathology
Carcinoma, Lobular therapy
Chemotherapy, Adjuvant
Combined Modality Therapy
Female
Follow-Up Studies
Humans
Mastectomy
Middle Aged
Neoplasm Grading
Neoplasm Recurrence, Local metabolism
Neoplasm Recurrence, Local therapy
Neoplasm Staging
Prognosis
Radiotherapy, Adjuvant
Receptors, Estrogen metabolism
Receptors, Progesterone metabolism
Retrospective Studies
Survival Rate
Biomarkers, Tumor metabolism
Breast Neoplasms metabolism
Carcinoma, Ductal, Breast metabolism
Carcinoma, Intraductal, Noninfiltrating metabolism
Carcinoma, Lobular metabolism
Neoplasm Recurrence, Local diagnosis
Receptor, ErbB-2 metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1791-7530
- Volume :
- 34
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 24596361