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[Effect of change to flutamide for prostate cancer patient who developed breast pain during bicalutamide treatment (BIP-F study)].
- Source :
-
Hinyokika kiyo. Acta urologica Japonica [Hinyokika Kiyo] 2014 Jan; Vol. 60 (1), pp. 17-23. - Publication Year :
- 2014
-
Abstract
- In Japan, prostate cancer is treated with non-steroidal anti-androgen (flutamide and bicalutamide). Development of breast pain during bicalutamide treatment, in prostate cancer patients reduces their quality of life (QOL) and treatment compliance. We studied the safety and effectiveness of switching from bicalutamide to flutamide in 13 prostate cancer patients who developed breast pain during bicalutamide treatment. We estimated the change in breast pain using a face scale and the Expanded Prostate Cancer Index Composite (EPIC) and EPIC-hormone domain (HD) score. The switch to flutamide relieved breast pain in nine patients, had no effect in one patient, and increased breast pain in two patients. One patient dropped out. Furthermore, summary score and hormone function were improved with a significant difference in the EPIC-HD score. Switching to flutamide in prostate cancer patients who develop breast pain during bicalutamide is safe and effective.
- Subjects :
- Aged
Aged, 80 and over
Drug Administration Schedule
Humans
Male
Mastodynia diagnosis
Middle Aged
Pain Measurement methods
Surveys and Questionnaires
Treatment Outcome
Androgen Antagonists administration & dosage
Androgen Antagonists adverse effects
Anilides adverse effects
Antineoplastic Agents administration & dosage
Antineoplastic Agents adverse effects
Drug Substitution
Flutamide administration & dosage
Mastodynia chemically induced
Mastodynia prevention & control
Nitriles adverse effects
Prostatic Neoplasms drug therapy
Tosyl Compounds adverse effects
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0018-1994
- Volume :
- 60
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Hinyokika kiyo. Acta urologica Japonica
- Publication Type :
- Academic Journal
- Accession number :
- 24594768