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[In vitro derivation and characterization of a colorectal cancer stem cell subpopulation].
- Source :
-
Tsitologiia [Tsitologiia] 2013; Vol. 55 (5), pp. 318-23. - Publication Year :
- 2013
-
Abstract
- In present publication we describe for the first time the obtainment of cancer stem cells from a weakly metastatic human colorectal carcinoma cell line MIP101 via selecting from the native population the cells that express intensively an embryonic stem cell marker, POU5F1 (Oct4). We provide the evidence that these cells possess an elevated clonogenic and tumorigenic potential when compared to the native population, and this correlates to the hypothesis of cancer stem cells' primary role in the development of malignant neoplasms.
- Subjects :
- Animals
Biomarkers, Tumor genetics
Cell Line, Tumor
Cell Lineage genetics
Colorectal Neoplasms etiology
Colorectal Neoplasms pathology
Embryonic Stem Cells metabolism
Gene Expression Regulation, Neoplastic
Humans
Mice
Neoplasm Metastasis genetics
Neoplasm Metastasis pathology
Neoplastic Stem Cells metabolism
Colorectal Neoplasms genetics
Embryonic Stem Cells cytology
Neoplastic Stem Cells cytology
Octamer Transcription Factor-3 biosynthesis
Subjects
Details
- Language :
- Russian
- ISSN :
- 0041-3771
- Volume :
- 55
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Tsitologiia
- Publication Type :
- Academic Journal
- Accession number :
- 24592739