Back to Search
Start Over
Cutting edge: control of Mycobacterium tuberculosis infection by a subset of lung parenchyma-homing CD4 T cells.
- Source :
-
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2014 Apr 01; Vol. 192 (7), pp. 2965-9. Date of Electronic Publication: 2014 Mar 03. - Publication Year :
- 2014
-
Abstract
- Th1 cells are critical for containment of Mycobacterium tuberculosis infection, but little else is known about the properties of protective CD4 T cell responses. In this study, we show that the pulmonary Th1 response against M. tuberculosis is composed of two populations that are either CXCR3(hi) and localize to lung parenchyma or are CX3CR1(hi)KLRG1(hi) and are retained within lung blood vasculature. M. tuberculosis-specific parenchymal CD4 T cells migrate rapidly back into the lung parenchyma upon adoptive transfer, whereas the intravascular effectors produce the highest levels of IFN-γ in vivo. Importantly, parenchymal T cells displayed greater control of infection compared with the intravascular counterparts upon transfer into susceptible T cell-deficient hosts. Thus, we identified a subset of naturally generated M. tuberculosis-specific CD4 T cells with enhanced protective capacity and showed that control of M. tuberculosis correlates with the ability of CD4 T cells to efficiently enter the lung parenchyma rather than produce high levels of IFN-γ.
- Subjects :
- Adoptive Transfer
Animals
Blood Vessels immunology
Blood Vessels metabolism
CD4-Positive T-Lymphocytes metabolism
CD4-Positive T-Lymphocytes transplantation
CX3C Chemokine Receptor 1
Cell Movement immunology
Flow Cytometry
Host-Pathogen Interactions immunology
Interferon-gamma immunology
Interferon-gamma metabolism
Lectins, C-Type
Leukocyte Common Antigens immunology
Leukocyte Common Antigens metabolism
Lung blood supply
Lung microbiology
Mice
Mice, Congenic
Mice, Inbred C57BL
Mice, Knockout
Microscopy, Fluorescence
Mycobacterium tuberculosis physiology
Receptors, CXCR3 immunology
Receptors, CXCR3 metabolism
Receptors, Chemokine immunology
Receptors, Chemokine metabolism
Receptors, Immunologic immunology
Receptors, Immunologic metabolism
Th1 Cells immunology
Th1 Cells metabolism
Tuberculosis microbiology
CD4-Positive T-Lymphocytes immunology
Lung immunology
Mycobacterium tuberculosis immunology
Tuberculosis immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1550-6606
- Volume :
- 192
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of immunology (Baltimore, Md. : 1950)
- Publication Type :
- Academic Journal
- Accession number :
- 24591367
- Full Text :
- https://doi.org/10.4049/jimmunol.1400019