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Anxiolytic-like effect of danshensu [(3-(3,4-dihydroxyphenyl)-lactic acid)] in mice.
- Source :
-
Life sciences [Life Sci] 2014 Apr 17; Vol. 101 (1-2), pp. 73-8. Date of Electronic Publication: 2014 Feb 25. - Publication Year :
- 2014
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Abstract
- Aims: Danshensu [3-(3,4-dihydroxyphenyl)-lactic acid], a phenylpropanoid compound isolated from Prunella vulgaris var. lilacina, is a well-known antioxidant. Although its antioxidant activity and cardioprotective effect have been reported, the pharmacological properties of danshensu in the central nervous system remain unclear. We investigated whether danshensu exerts anxiolytic-like activity in mice.<br />Main Methods: We conducted monoamine oxidase A (MAO-A) inhibition assay on danshensu in vitro, and behavioral tests including the elevated plus-maze test (EPM), the hole-board test, the rotarod test and the open field test were employed.<br />Key Findings: We found that danshensu significantly inhibited the activity of MAO-A in vitro. The administration of danshensu (3 or 10mg/kg) produced a significant anxiolytic-like effect in the EPM and hole-board test. In addition, no changes in the spontaneous locomotor activity and no myorelaxant effects were observed compared to the control group; these effects were confirmed with the open field test and the rotarod test. Moreover, the anxiolytic-like properties of danshensu were antagonized by a dopamine D1 receptor antagonist (SCH 23390) but not by a 5-HT1A receptor antagonist (WAY 100635) or an α1-adrenergic receptor antagonist (prazosin).<br />Significance: These results indicate that danshensu exerts its anxiolytic-like properties, in part, through dopaminergic neurotransmitter signaling.<br /> (Copyright © 2014 Elsevier Inc. All rights reserved.)
- Subjects :
- Adrenergic alpha-1 Receptor Antagonists pharmacology
Animals
Anti-Anxiety Agents antagonists & inhibitors
Benzazepines pharmacology
Dopamine Antagonists pharmacology
Dose-Response Relationship, Drug
Drug Interactions
Exploratory Behavior drug effects
Lactates antagonists & inhibitors
Male
Maze Learning drug effects
Mice
Monoamine Oxidase Inhibitors pharmacology
Motor Activity drug effects
Muscle Relaxation drug effects
Piperazines pharmacology
Prazosin pharmacology
Pyridines pharmacology
Rotarod Performance Test
Serotonin Antagonists pharmacology
Anti-Anxiety Agents pharmacology
Lactates pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0631
- Volume :
- 101
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Life sciences
- Publication Type :
- Academic Journal
- Accession number :
- 24582592
- Full Text :
- https://doi.org/10.1016/j.lfs.2014.02.011