Back to Search
Start Over
Antiphosphotyrosine recovery of phospholipase C activity after EGF treatment of A-431 cells.
- Source :
-
Science (New York, N.Y.) [Science] 1988 Aug 19; Vol. 241 (4868), pp. 968-70. - Publication Year :
- 1988
-
Abstract
- A tenfold increase in phospholipase C activity specific for phosphatidylinositol 4,5-bisphosphate (PIP2) was immunopurified from extracts of A-431 epidermoid carcinoma cells stimulated with epidermal growth factor. This finding suggests a biochemical link between growth factor-stimulated tyrosine kinase activity and PIP2 hydrolysis.
- Subjects :
- Antibodies immunology
Carcinoma, Squamous Cell
Chromatography, High Pressure Liquid
Cytosol enzymology
Hydrolysis
Inositol Phosphates metabolism
Phosphatidylinositol 4,5-Diphosphate
Phosphatidylinositols metabolism
Phosphorylation
Phosphotyrosine
Protein-Tyrosine Kinases metabolism
Substrate Specificity
Tumor Cells, Cultured
Tyrosine immunology
Tyrosine metabolism
Epidermal Growth Factor pharmacology
Type C Phospholipases metabolism
Tyrosine analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 0036-8075
- Volume :
- 241
- Issue :
- 4868
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 2457254
- Full Text :
- https://doi.org/10.1126/science.2457254