First report of KPC-2 Carbapenemase-producing Klebsiella pneumoniae in Japan.

Authors :: Saito R
Takahashi R
Sawabe E
Koyano S
Takahashi Y
Shima M
Ushizawa H
Fujie T
Tosaka N
Kato Y
Moriya K
Tohda S
Tojo N
Koike R
Kubota T
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2014 May; Vol. 58 (5), pp. 2961-3. Date of Electronic Publication: 2014 Feb 24.
Publication Year :: 2014
Abstract: We investigated a novel Japanese isolate of sequence type 11 (ST11), the Klebsiella pneumoniae carbapenemase-2 (KPC-2)-producing K. pneumoniae strain Kp3018, which was previously obtained from a patient treated at a Brazilian hospital. This strain was resistant to various antibiotic classes, including carbapenems, and harbored the gene blaKPC-2, which was present on the transferable plasmid of ca. 190 kb, in addition to the blaCTX-M-15 gene. Furthermore, the ca. 2.3-kb sequences (ISKpn8-blaKPC-2-ISKpn6-like), encompassing blaKPC-2, were found to be similar to those of K. pneumoniae strains from China.