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Exocyst proteins in cytokinesis: Regulation by Rab11.

Authors :
Neto H
Balmer G
Gould G
Source :
Communicative & integrative biology [Commun Integr Biol] 2013 Nov 01; Vol. 6 (6), pp. e27635. Date of Electronic Publication: 2014 Jan 08.
Publication Year :
2013

Abstract

The Exocyst is an octameric protein complex comprised of Sec3, Sec5, Sec6, Sec8, Sec10, Sec15, Exo70, and Exo84 subunits.(1, 2) This complex was first identified in budding yeast where it acts to target vesicles to the bud tip and the cleavage furrow.(3) Here, we show that all Exocyst subunits are required for cytokinesis in mammalian cells. We further show that a subset of Exocyst proteins are differentially regulated by Rab11, consistent with recent studies implicating Rab11 vesicles in Exocyst protein trafficking.

Details

Language :
English
ISSN :
1942-0889
Volume :
6
Issue :
6
Database :
MEDLINE
Journal :
Communicative & integrative biology
Publication Type :
Academic Journal
Accession number :
24563720
Full Text :
https://doi.org/10.4161/cib.27635