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Pioneering axons regulate neuronal polarization in the developing cerebral cortex.
- Source :
-
Neuron [Neuron] 2014 Feb 19; Vol. 81 (4), pp. 814-29. - Publication Year :
- 2014
-
Abstract
- The polarization of neurons, which mainly includes the differentiation of axons and dendrites, is regulated by cell-autonomous and non-cell-autonomous factors. In the developing central nervous system, neuronal development occurs in a heterogeneous environment that also comprises extracellular matrices, radial glial cells, and neurons. Although many cell-autonomous factors that affect neuronal polarization have been identified, the microenvironmental cues involved in neuronal polarization remain largely unknown. Here, we show that neuronal polarization occurs in a microenvironment in the lower intermediate zone, where the cell adhesion molecule transient axonal glycoprotein-1 (TAG-1) is expressed in cortical efferent axons. The immature neurites of multipolar cells closely contact TAG-1-positive axons and generate axons. Inhibition of TAG-1-mediated cell-to-cell interaction or its downstream kinase Lyn impairs neuronal polarization. These results show that the TAG-1-mediated cell-to-cell interaction between the unpolarized multipolar cells and the pioneering axons regulates the polarization of multipolar cells partly through Lyn kinase and Rac1.<br /> (Copyright © 2014 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Cell Adhesion Molecules, Neuronal metabolism
Cell Differentiation physiology
Cerebral Cortex cytology
Cerebral Cortex metabolism
Dendrites metabolism
Mice
Neurogenesis physiology
Axons metabolism
Cerebral Cortex growth & development
Contactin 2 metabolism
Neuropeptides metabolism
rac1 GTP-Binding Protein metabolism
src-Family Kinases metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1097-4199
- Volume :
- 81
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Neuron
- Publication Type :
- Academic Journal
- Accession number :
- 24559674
- Full Text :
- https://doi.org/10.1016/j.neuron.2013.12.015