Back to Search
Start Over
Particle replication in nonwetting templates nanoparticles with tumor selective alkyl silyl ether docetaxel prodrug reduces toxicity.
- Source :
-
Nano letters [Nano Lett] 2014 Mar 12; Vol. 14 (3), pp. 1472-6. Date of Electronic Publication: 2014 Feb 24. - Publication Year :
- 2014
-
Abstract
- Delivery systems designed to have triggered release after passively targeting the tumor may improve small molecule chemotherapeutic delivery. Particle replication in nonwetting templates was used to prepare nanoparticles to passively target solid tumors in an A549 subcutaneous xenograft model. An acid labile prodrug was delivered to minimize systemic free docetaxel concentrations and improve tolerability without compromising efficacy.
- Subjects :
- Animals
Docetaxel
Humans
Mice
Nanoparticles ultrastructure
Neoplasms pathology
Wettability
Xenograft Model Antitumor Assays
Drug Carriers chemistry
Drug Carriers pharmacology
Nanoparticles chemistry
Neoplasms drug therapy
Prodrugs chemistry
Prodrugs pharmacology
Taxoids chemistry
Taxoids pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1530-6992
- Volume :
- 14
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Nano letters
- Publication Type :
- Academic Journal
- Accession number :
- 24552251
- Full Text :
- https://doi.org/10.1021/nl4046558