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Rapid assessment of protecting-group stability by using a robustness screen.
- Source :
-
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2014 Mar 24; Vol. 20 (13), pp. 3800-5. Date of Electronic Publication: 2014 Feb 19. - Publication Year :
- 2014
-
Abstract
- An experimentally simple method has been developed to rapidly establish the stability of widely utilized silyl, acetal, and carbamate protecting groups to a given set of reaction conditions. Assessment of up to twelve protecting groups in a single experiment has been demonstrated. Evaluation of this protocol in two unrelated synthetic transformations suggests that this method can be used to select appropriate protecting groups in the design of synthetic routes.<br /> (© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Details
- Language :
- English
- ISSN :
- 1521-3765
- Volume :
- 20
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- Chemistry (Weinheim an der Bergstrasse, Germany)
- Publication Type :
- Academic Journal
- Accession number :
- 24550131
- Full Text :
- https://doi.org/10.1002/chem.201304508