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Predictive value of volumetric parameters measured by F-18 FDG PET/CT for lymph node status in patients with surgically resected rectal cancer.
- Source :
-
Annals of nuclear medicine [Ann Nucl Med] 2014 Apr; Vol. 28 (3), pp. 196-202. Date of Electronic Publication: 2014 Feb 15. - Publication Year :
- 2014
-
Abstract
- Objective: The objective of this study was to investigate the predictive role of volumetric parameters such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG) measured by F-18 FDG PET/CT for regional lymph node (rLN) metastasis in rectal cancer patients.<br />Methods: Retrospectively, 74 rectal cancer patients were enrolled. All patients received surgical treatment and F-18 FDG PET/CT at diagnosis. The F-18 FDG PET/CT findings of primary cancer and rLN involvement were compared with the pathologic diagnosis within 5 weeks after operation. Univariate and multivariate analyses were used to analyze the associations among the pathologic LN status and age, sex, T stage, AJCC stage, SUVmax, lymphatic invasion, venous invasion, neural invasion, and volumetric parameters.<br />Results: The LN (+) group showed statistically significant higher values of MTV2.5 (p < 0.0001), MTV3 (p < 0.0001), MTV3.5 (p = 0.0001), TLG2.5 (p = 0.0007), TLG3 (p = 0.0011), and TLG3.5 (p = 0.0024). In univariate analysis, T stage, AJCC stage, neural invasion, and volumetric parameters were factors significantly associated with pathologic LN involvement. However, in multivariate analysis, advanced T stage, high AJCC stage, MTV2.5, and TLG2.5 were associated with pathologic LN involvement in rectal cancer.<br />Conclusion: This study showed that, not only T stage and AJCC stage, but also volumetric parameters such as MTV2.5 and TLG2.5 are useful factors for the prediction of pathologic LN status in rectal cancer patients.
- Subjects :
- Adult
Aged
Female
Humans
Lymphatic Metastasis
Male
Middle Aged
Predictive Value of Tests
Rectal Neoplasms surgery
Retrospective Studies
Fluorodeoxyglucose F18
Multimodal Imaging
Positron-Emission Tomography
Rectal Neoplasms diagnosis
Rectal Neoplasms pathology
Tomography, X-Ray Computed
Tumor Burden
Subjects
Details
- Language :
- English
- ISSN :
- 1864-6433
- Volume :
- 28
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Annals of nuclear medicine
- Publication Type :
- Academic Journal
- Accession number :
- 24532377
- Full Text :
- https://doi.org/10.1007/s12149-014-0809-x