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Sinugyrosanolide A, an unprecedented C-4 norcembranoid, from the Formosan soft coral Sinularia gyrosa.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2014 Mar 15; Vol. 24 (6), pp. 1562-4. Date of Electronic Publication: 2014 Feb 03. - Publication Year :
- 2014
-
Abstract
- Chemical investigations on the acetone extract of the Formosan soft coral Sinularia gyrosa have obtained a novel C-4 norcembranoid possessing an unprecedented tricyclo[9.3.0.0(3,8)]tetradecane skeleton, namely sinugyrosanolide A. The NMR spectroscopic data of the novel norcembranoid were completely assigned by using a combination of 2D NMR experiments including (1)H-(1)H COSY, HSQC, HMBC, and NOESY. The cytotoxicities, anti-HCMV (human cytomegalovirus) endonuclease activities and antibacterial activities were evaluated in vitro. It showed moderate cytotoxicity against P-388 (mouse lymphocytic leukemia) cancer cell line with an EC50 of 11.8μM.<br /> (Copyright © 2014 Elsevier Ltd. All rights reserved.)
- Subjects :
- Alkanes chemistry
Animals
Anthozoa metabolism
Anti-Bacterial Agents isolation & purification
Anti-Bacterial Agents pharmacology
Bacteria drug effects
Carbon chemistry
Cell Line, Tumor
Cell Survival drug effects
Cytomegalovirus enzymology
Diterpenes isolation & purification
Diterpenes pharmacology
Endonucleases antagonists & inhibitors
Endonucleases metabolism
Humans
Magnetic Resonance Spectroscopy
Mice
Molecular Conformation
Viral Proteins antagonists & inhibitors
Viral Proteins metabolism
Anthozoa chemistry
Anti-Bacterial Agents chemistry
Diterpenes chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 24
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 24529868
- Full Text :
- https://doi.org/10.1016/j.bmcl.2014.01.073