Prevalence, specificity and functionality of anti-ganglioside antibodies in neuropathy associated with IgM monoclonal gammopathy.

Authors :: Stork AC
Jacobs BC
Tio-Gillen AP
Eurelings M
Jansen MD
van den Berg LH
Notermans NC
van der Pol WL
Source :: Journal of neuroimmunology [J Neuroimmunol] 2014 Mar 15; Vol. 268 (1-2), pp. 89-94. Date of Electronic Publication: 2014 Jan 29.
Publication Year :: 2014
Abstract: IgM antibodies against gangliosides and their complexes were studied in sera from 54 patients with polyneuropathy and IgM monoclonal gammopathy (IgM-PNP) without anti-MAG antibodies. Anti-ganglioside antibodies were found in 19 (35%) patients. Five (9%) patients had antibodies against ganglioside complexes. IgM antibodies against gangliosides activated complement in vitro. Light chain usage was restricted to kappa or lambda in most, but not all patients. In conclusion, anti-ganglioside antibodies in IgM-PNP are common, display pathogenic properties and do not always arise from a monoclonal B cell proliferation.<br /> (Copyright © 2014 Elsevier B.V. All rights reserved.)

Full Text Access

Tools