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Are hypertriglyceridemia and low HDL causal factors in the development of insulin resistance?
- Source :
-
Atherosclerosis [Atherosclerosis] 2014 Mar; Vol. 233 (1), pp. 130-8. Date of Electronic Publication: 2014 Jan 07. - Publication Year :
- 2014
-
Abstract
- Insulin resistance often occurs with dyslipidemia as part of the metabolic syndrome and the current dominant paradigm is that insulin resistance leads to dyslipidemia. However, dyslipidemia may also cause insulin resistance; this was postulated 30 years ago, but has never been substantiated. Establishing whether dyslipidemia plays a causal role in the etiology of insulin resistance is important since it could reveal new avenues for combating type 2 diabetes. In this review we summarize recent evidence from epidemiological, genetic and intervention studies to re-address this old hypothesis.<br /> (Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Cholesterol, HDL metabolism
Dyslipidemias complications
Genome-Wide Association Study
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use
Hypertriglyceridemia complications
Insulin Resistance genetics
Metabolic Syndrome complications
Diabetes Mellitus, Type 2 prevention & control
Insulin Resistance physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1484
- Volume :
- 233
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Atherosclerosis
- Publication Type :
- Academic Journal
- Accession number :
- 24529133
- Full Text :
- https://doi.org/10.1016/j.atherosclerosis.2013.12.013