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Clearance studies on the renal action of porins extracted from Salmonella typhimurium.
- Source :
-
The International journal of pediatric nephrology [Int J Pediatr Nephrol] 1987 Oct-Dec; Vol. 8 (4), pp. 193-8. - Publication Year :
- 1987
-
Abstract
- The effects of porins on renal hemodynamics and on the renal handling of salt and water were studied in rats. The animals injected with 100 micrograms/kg of porins showed an important change in renal potassium handling. In fact the total potassium excretion decreased significantly (p less than 0.02) from 1.11 +/- 0.13 to 0.495 +/- 0.069 muEq/min/100 g and was significantly associated to a reduction of fractional potassium excretion from 21.6 +/- 4.1% to 12.53 +/- 0.95% (p less than 0.001). It is speculated that porins have the capability to close the potassium channels.
- Subjects :
- Animals
Bacterial Outer Membrane Proteins isolation & purification
Biological Transport drug effects
Ion Channels drug effects
Male
Porins
Potassium metabolism
Rats
Rats, Inbred Strains
Sodium metabolism
Bacterial Outer Membrane Proteins pharmacology
Salmonella typhimurium
Urodynamics drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0391-6510
- Volume :
- 8
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The International journal of pediatric nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 2452800