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Enhanced proteolysis of bovine fibrinogen in the presence of polysulfates.
- Source :
-
Thrombosis research [Thromb Res] 1988 Jan 15; Vol. 49 (2), pp. 181-91. - Publication Year :
- 1988
-
Abstract
- Proteolysis of fibrinogen by bovine trypsin and chymotrypsin was enhanced by heparin, dextran sulfate (DS) and polyvinyl sulfate (PVS) in the presence of 0.1 M NaCl. Decrease in intrinsic fluorescence of fibrinogen with time was also enhanced by DS and PVS in the absence of NaCl, but not in the presence of 0.1 M NaCl. Thus, increase in susceptibility of fibrinogen to proteases in the presence of three polysulfate was more sensitive than time-dependent conformational change of the substrate protein.
Details
- Language :
- English
- ISSN :
- 0049-3848
- Volume :
- 49
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Thrombosis research
- Publication Type :
- Academic Journal
- Accession number :
- 2452493
- Full Text :
- https://doi.org/10.1016/0049-3848(88)90212-5