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Protection of 4-hydroxybenzyl-chitooligomers against inflammatory responses in Chang liver cells.
- Source :
-
International journal of biological macromolecules [Int J Biol Macromol] 2014 May; Vol. 66, pp. 1-6. Date of Electronic Publication: 2014 Feb 09. - Publication Year :
- 2014
-
Abstract
- The aim of this study was to investigate anti-inflammatory activity of 4-hydroxybenzyl-chitooligomers (HB-COS) in Chang liver cells stimulated by a cytokine mixture. It was revealed that HB-COS decreased the level of nitric oxide and prostaglandin E2 (PGE2) production by diminishing the expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) without significant cytotoxicity. Moreover, HB-COS exerted inhibitory effects on the production of pro-inflammatory mediator (interleukin-6) in Chang liver cells. Notably, HB-COS exhibited anti-inflammatory activities via blocking degradation of inhibitory kappa B alpha (IκB-α), translocation of nuclear factor kappa B (NF-κB), and phosphorylation of mitogen-activated protein kinases (MAPKs) in a dose-dependent manner. Collectively, these findings indicated that HB-COS possessed potential anti-inflammatory effects in Chang liver cells, and could be a useful therapeutic agent for the treatment of hepatic inflammatory diseases.<br /> (Copyright © 2014 Elsevier B.V. All rights reserved.)
- Subjects :
- Cell Line
Cyclooxygenase 2 metabolism
Dinoprostone metabolism
Humans
I-kappa B Proteins metabolism
Inflammation metabolism
Interleukin-6 metabolism
Liver metabolism
Mitogen-Activated Protein Kinases metabolism
NF-KappaB Inhibitor alpha
NF-kappa B metabolism
Nitric Oxide metabolism
Nitric Oxide Synthase Type II metabolism
Phosphorylation drug effects
Anti-Inflammatory Agents pharmacology
Inflammation drug therapy
Liver drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0003
- Volume :
- 66
- Database :
- MEDLINE
- Journal :
- International journal of biological macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 24521568
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2014.01.064