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Iridium-catalyzed enantioselective allyl-alkene coupling.
- Source :
-
Journal of the American Chemical Society [J Am Chem Soc] 2014 Feb 26; Vol. 136 (8), pp. 3006-9. Date of Electronic Publication: 2014 Feb 12. - Publication Year :
- 2014
-
Abstract
- The direct Ir-catalyzed cross-coupling between branched, racemic allylic alcohols and simple olefins is described. This transformation is catalyzed by an Ir-(P,olefin) complex and proceeds with high site selectivity and excellent enantioselectivity. The method allows rapid access to various 1,5-dienes or trienes and was used in the catalytic asymmetric synthesis of the γ-secretase modulator JNJ-40418677.
Details
- Language :
- English
- ISSN :
- 1520-5126
- Volume :
- 136
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- 24521052
- Full Text :
- https://doi.org/10.1021/ja412962w