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Degradation of centromeric histone H3 variant Cse4 requires the Fpr3 peptidyl-prolyl Cis-Trans isomerase.
- Source :
-
Genetics [Genetics] 2014 Apr; Vol. 196 (4), pp. 1041-5. Date of Electronic Publication: 2014 Feb 10. - Publication Year :
- 2014
-
Abstract
- The centromeric histone H3 variant Cse4 in Saccharomyces cerevisiae is polyubiquitylated and degraded in a proteasome-dependent manner. We report here that the proline isomerase Fpr3 regulates Cse4 proteolysis. Structural change in Cse4 by Fpr3 might be important for the interaction between Cse4 and the E3 ubiquitin ligase Psh1.
- Subjects :
- Chromosomal Instability
Chromosomes, Fungal
Immunophilins genetics
Mitosis
Proteasome Endopeptidase Complex metabolism
Proteolysis
Saccharomyces cerevisiae growth & development
Saccharomyces cerevisiae Proteins genetics
Ubiquitination
Chromosomal Proteins, Non-Histone metabolism
DNA-Binding Proteins metabolism
Immunophilins metabolism
Peptide Elongation Factors metabolism
Saccharomyces cerevisiae metabolism
Saccharomyces cerevisiae Proteins metabolism
Ubiquitin-Protein Ligases metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1943-2631
- Volume :
- 196
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 24514906
- Full Text :
- https://doi.org/10.1534/genetics.114.161224