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Grape seed proanthocyanidin extract prevents DDP-induced testicular toxicity in rats.
- Source :
-
Food & function [Food Funct] 2014 Mar; Vol. 5 (3), pp. 605-11. - Publication Year :
- 2014
-
Abstract
- Oxidative stress has been proven to be involved in cisplatin (DDP)-induced toxicity. The aim of the present study was to investigate a possible protective role of grape seed proanthocyanidin extract (GSPE) in DDP-induced spermiotoxicity. GSPE at 200 mg kg(-1) d(-1) and 400 mg kg(-1) d(-1) was orally administered for 15 consecutive days, starting 10 days before a single intraperitoneal dose of DDP (7 mg kg(-1)). Results revealed that testicular and epididymal weight, epididymal sperm count, motility and morphology, the activities of GSH-Px and SOD, and GSH levels were significantly decreased whereas the level of MDA was significantly increased in the DDP group rats. GSPE treatment significantly attenuated the harmful effects of DDP-induced lipid peroxidation, oxidative stress, loss of genital organ weight, as well as function of reproductive organs. These changes were restored to near normal levels by GSPE at 400 mg kg(-1) d(-1). In conclusion, GSPE has dose dependent protective effects against DDP-induced rat testicular toxicity.
- Subjects :
- Animals
Glutathione metabolism
Lipid Peroxidation drug effects
Male
Oxidative Stress drug effects
Rats
Rats, Sprague-Dawley
Sperm Count
Sperm Motility drug effects
Testis cytology
Antineoplastic Agents toxicity
Cisplatin toxicity
Grape Seed Extract administration & dosage
Proanthocyanidins administration & dosage
Testis drug effects
Testis metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2042-650X
- Volume :
- 5
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Food & function
- Publication Type :
- Academic Journal
- Accession number :
- 24504493
- Full Text :
- https://doi.org/10.1039/c3fo60486a