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A meta-analysis of coffee intake and risk of urolithiasis.

Authors :: Wang S
Zhang Y
Mao Z
He X
Zhang Q
Zhang D
Source :: Urologia internationalis [Urol Int] 2014; Vol. 93 (2), pp. 220-8. Date of Electronic Publication: 2014 Feb 06.
Publication Year :: 2014
Abstract: Objective: Epidemiologic studies have reported various results relating coffee to urolithiasis. A meta-analysis of cohort and case-control studies was conducted to pool the relative risk (RR) estimates of the association between coffee and urolithiasis.<br />Methods: Eligible studies were retrieved via both computer searches and review of references. We analyzed abstracted data with random effects models to obtain the summary RR estimates. A dose-response meta-analysis was performed for studies reporting categorical RR estimates for a series of exposure levels.<br />Results: A total of 6 studies (2 cohort and 4 case-control studies) on coffee intake were included in the meta-analysis. The pooled odds ratio (OR) showed a significant influence of the highest coffee consumption (OR = 0.70, 95% confidence interval 0.60-0.82) on the risk of urolithiasis. Coffee exhibited an inverse dose-response relationship with urolithiasis. In stratified analysis, a significant inverse association between coffee and urolithiasis was observed in study design, geographical region and gender subgroup.<br />Conclusions: The overall current literature suggests that coffee intake is associated with a decreased risk of urolithiasis. Further efforts should be made to clarify the underlying biological mechanisms.<br /> (2014 S. Karger AG, Basel.)