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Protective effect of magnesium preloading on cisplatin-induced nephrotoxicity: a retrospective study.
- Source :
-
Japanese journal of clinical oncology [Jpn J Clin Oncol] 2014 Apr; Vol. 44 (4), pp. 346-54. Date of Electronic Publication: 2014 Feb 05. - Publication Year :
- 2014
-
Abstract
- Objective: Magnesium supplementation has been reported to have a nephroprotective effect on cisplatin-induced renal dysfunction, but little evidence exists regarding the effect of magnesium preloading before cisplatin administration. We started to include magnesium preloading (8 mEq) in cisplatin-containing treatment regimens in January 2011. The aim of the present study was to evaluate whether magnesium preloading reduces cisplatin-induced nephrotoxicity.<br />Methods: We retrospectively reviewed 496 thoracic malignancy patients treated with cisplatin (≥60 mg/m²)-containing regimens as a first-time chemotherapy between January 2009 and December 2011. We compared the incidence of Grade ≥2 serum creatinine elevation according to the Common Terminology Criteria for Adverse Events, version 4.0, between magnesium preloading group (n = 161 [32%]) and non-magnesium preloading group (n = 335 [68%]) during the first cycle and all cycles.<br />Results: The median number of administered cycles was four in both groups. The incidence of Grade ≥2 serum creatinine elevation in magnesium preloading group was significantly lower during both the first cycle and all cycles than in the non-magnesium preloading group (4.9 versus 19.1% during the first cycle, and 14.2 versus 39.7% during all the cycles). A multivariate analysis indicated that magnesium preloading significantly reduced cisplatin-induced nephrotoxicity throughout the entire period from after the first administration (odds ratio: 0.262, 95% confidence interval: 0.106-0.596 during the first cycle, and odds ratio: 0.234, 95% confidence interval: 0.129-0.414 during all cycles).<br />Conclusions: Magnesium preloading before cisplatin administration significantly reduced cisplatin-induced nephrotoxicity.
- Subjects :
- Acute Kidney Injury blood
Acute Kidney Injury physiopathology
Adult
Aged
Analysis of Variance
Antineoplastic Agents administration & dosage
Biomarkers blood
Cisplatin administration & dosage
Drug Administration Schedule
Female
Fluid Therapy
Humans
Incidence
Kidney pathology
Kidney physiopathology
Magnesium blood
Male
Middle Aged
Odds Ratio
Primary Prevention methods
Retrospective Studies
Severity of Illness Index
Treatment Outcome
Acute Kidney Injury chemically induced
Acute Kidney Injury prevention & control
Antineoplastic Agents adverse effects
Cisplatin adverse effects
Creatinine blood
Kidney drug effects
Magnesium administration & dosage
Protective Agents administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1465-3621
- Volume :
- 44
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Japanese journal of clinical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 24503028
- Full Text :
- https://doi.org/10.1093/jjco/hyu004