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Antiphospholipid antibody syndrome.
- Source :
-
Obstetrics and gynecology clinics of North America [Obstet Gynecol Clin North Am] 2014 Mar; Vol. 41 (1), pp. 113-32. - Publication Year :
- 2014
-
Abstract
- Antiphospholipid antibodies (aPLs) are acquired antibodies directed against negatively charged phospholipids. Obstetric antiphospholipid antibody syndrome (APS) is diagnosed in the presence of certain clinical features in conjunction with positive laboratory findings. Obstetric APS is one of the most commonly identified causes of recurrent pregnancy loss. Thus, obstetric APS is distinguished from APS in other organ systems where the most common manifestation is thrombosis. Several pathophysiologic mechanisms of action of aPLs have been described. This article discusses the diagnostic and obstetric challenges of obstetric APS, proposed pathophysiologic mechanisms of APS during pregnancy, and the management of women during and after pregnancy.<br /> (Copyright © 2014 Elsevier Inc. All rights reserved.)
- Subjects :
- Abortion, Habitual drug therapy
Abortion, Habitual etiology
Antiphospholipid Syndrome complications
Antiphospholipid Syndrome drug therapy
Aspirin therapeutic use
Female
Fibrinolytic Agents therapeutic use
Heparin therapeutic use
Humans
Placental Insufficiency etiology
Pregnancy
Pregnancy Complications drug therapy
Abortion, Habitual immunology
Antibodies, Antiphospholipid immunology
Antiphospholipid Syndrome immunology
Placental Insufficiency immunology
Pregnancy Complications immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1558-0474
- Volume :
- 41
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Obstetrics and gynecology clinics of North America
- Publication Type :
- Academic Journal
- Accession number :
- 24491987
- Full Text :
- https://doi.org/10.1016/j.ogc.2013.10.004