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Treatment of myopic choroidal neovascularization with posterior sub-Tenon's bevacizumab injection (Avastin ®).
- Source :
-
International ophthalmology [Int Ophthalmol] 2014 Aug; Vol. 34 (4), pp. 971-7. Date of Electronic Publication: 2014 Feb 02. - Publication Year :
- 2014
-
Abstract
- The aim of this study was to report the successful treatment of choroidal neovascularization (CNV) in pathologic myopia (PM) with a posterior sub-Tenon bevacizumab (PSTB; Avastin(®)) injection. The study was a prospective case series including nine eyes of eight patients with PM and CNV. All nine eyes were injected with PSTB (12.5 mg/0.5 ml). Treatment effectiveness was evaluated with optical coherence tomography (OCT). If intraretinal edema or subretinal fluid were detected, injections were repeated after 2 weeks. The main outcome measures were logMAR best-corrected visual acuity (BCVA) and central foveal thickness. The mean follow-up time was 77.56 weeks. BCVA improved by a mean of -0.38 logMAR (>3 lines). The average reduction in absolute central foveal thickness was 25.67 μm. OCT revealed marked CNV volume reduction and fluid-free status in seven eyes. The fluid-free status remained for ≥ 1 year in these eyes. Fluorescein angiography revealed CNV resolution in three eyes. Corneal stromal penetration of subconjunctival bevacizumab has been demonstrated in animal studies. PSTB may be an equally effective, yet less invasive alternative for the treatment of myopic CNV.
- Subjects :
- Adult
Aged
Bevacizumab
Choroidal Neovascularization complications
Female
Follow-Up Studies
Humans
Injections, Intraocular
Middle Aged
Prospective Studies
Visual Acuity
Young Adult
Angiogenesis Inhibitors administration & dosage
Antibodies, Monoclonal, Humanized administration & dosage
Choroidal Neovascularization drug therapy
Myopia complications
Subjects
Details
- Language :
- English
- ISSN :
- 1573-2630
- Volume :
- 34
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- International ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 24488041
- Full Text :
- https://doi.org/10.1007/s10792-014-9907-y