Back to Search
Start Over
Prognostic biomarkers in thyroid cancer.
- Source :
-
Virchows Archiv : an international journal of pathology [Virchows Arch] 2014 Mar; Vol. 464 (3), pp. 333-46. Date of Electronic Publication: 2014 Feb 01. - Publication Year :
- 2014
-
Abstract
- Thyroid carcinomas represent a challenging problem from the prognostic standpoint. Despite an overall good prognosis of the most frequent endocrine malignancy, 10-15 % of papillary thyroid carcinomas (PTCs) turn refractory to radioactive iodine therapy. The increased incidence of thyroid cancer has led to the search for solid prognostic biomarkers that predict the behaviour of these tumours. Clinical and histopathological prognostic factors remain the only safe elements to be used for diagnosis and prognosis of patients with thyroid tumours. Despite the huge amount of genetic information of thyroid tumours, very few new markers revealed diagnostic or prognostic value per se. BRAF mutation can have some value if associated to other clinico-pathological parameters, or in the particular setting of iodine refractory tumours. Others can prove interesting in the future as predictive biomarkers of therapeutic response, but more studies are needed to confirm these potential biomarkers.
- Subjects :
- Carcinoma, Papillary diagnosis
Carcinoma, Papillary genetics
Carcinoma, Papillary metabolism
Carcinoma, Papillary pathology
Humans
Mutation genetics
Pathology, Molecular methods
Prognosis
Thyroid Neoplasms diagnosis
Thyroid Neoplasms pathology
Biomarkers, Tumor metabolism
Thyroid Neoplasms genetics
Thyroid Neoplasms metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1432-2307
- Volume :
- 464
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Virchows Archiv : an international journal of pathology
- Publication Type :
- Academic Journal
- Accession number :
- 24487783
- Full Text :
- https://doi.org/10.1007/s00428-013-1521-2