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Hybrid molecules containing the A-domain of insulin-like growth factor-I and the B-chain of insulin have increased mitogenic activity relative to insulin.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 1987 Dec 16; Vol. 149 (2), pp. 672-9. - Publication Year :
- 1987
-
Abstract
- Two synthetic insulin-like compounds consisting of the B-chain of insulin linked via disulfide bonds to A chains corresponding to the A-domain or the A- and D-domains of insulin-like growth factor I (IGF-I) have been evaluated for mitogenic activity and for binding to IGF receptors and IGF carrier proteins. Both compounds are 3- to 5-fold more potent mitogens than insulin, and have a comparably increased affinity for the type I IGF receptor that mediates these mitogenic effects in chick embryo fibroblasts. Neither compound interacts with IGF carrier proteins. These results indicate that the A-domain of IGF-I is importantly involved in its growth-promoting properties.
- Subjects :
- Animals
Carrier Proteins metabolism
Chick Embryo
DNA biosynthesis
Humans
Insulin-Like Growth Factor Binding Proteins
Insulin-Like Growth Factor I metabolism
Rats
Receptor, Insulin metabolism
Receptors, Somatomedin
Structure-Activity Relationship
Insulin pharmacology
Insulin-Like Growth Factor I pharmacology
Mitogens pharmacology
Somatomedins pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0006-291X
- Volume :
- 149
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 2447882
- Full Text :
- https://doi.org/10.1016/0006-291x(87)90420-7