Back to Search
Start Over
Regulatory T cells are redirected to kill glioblastoma by an EGFRvIII-targeted bispecific antibody.
- Source :
-
Oncoimmunology [Oncoimmunology] 2013 Dec 01; Vol. 2 (12), pp. e26757. Date of Electronic Publication: 2013 Oct 22. - Publication Year :
- 2013
-
Abstract
- Regulatory T cells (Tregs) play a central role in in tumor escape from immunosurveillance. We report that a bispecific T-cell engager (BiTE) targeting a mutated form of the epidermal growth factor receptor, i.e., EGFRvIII, potently redirects Tregs to kill glioblastoma through the granzyme-perforin pathway.
Details
- Language :
- English
- ISSN :
- 2162-4011
- Volume :
- 2
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Oncoimmunology
- Publication Type :
- Academic Journal
- Accession number :
- 24475376
- Full Text :
- https://doi.org/10.4161/onci.26757