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The microbiome and psoriatic arthritis.
- Source :
-
Current rheumatology reports [Curr Rheumatol Rep] 2014 Mar; Vol. 16 (3), pp. 407. - Publication Year :
- 2014
-
Abstract
- Psoriatic arthritis is a chronic inflammatory joint disease, seen in combination with the chronic inflammatory skin disease psoriasis and belonging to the family of spondylarthritides (SpA). A link is recognized between psoriatic arthritis and inflammatory bowel disease (IBD). Environmental factors seem to induce inflammatory disease in individuals with underlying genetic susceptibility. The microbiome is a subject of increasing interest in the etiology of these inflammatory immune-mediated diseases. The intestinal microbiome is able to affect extra-intestinal distant sites, including the joints, through immunomodulation. At this point, evidence regarding a relationship between the microbiome and psoriatic arthritis is scarce. However, we hypothesize that common immune-mediated inflammatory pathways seen in the "skin-joint-gut axis" in psoriatic arthritis are induced or at least mediated by the microbiome. Th17 has a crucial function in this mechanism. Further establishment of this connection may lead to novel therapeutic approaches for psoriatic arthritis.
- Subjects :
- Anti-Bacterial Agents therapeutic use
Arthritis, Psoriatic drug therapy
Arthritis, Psoriatic immunology
Autoimmunity
Feces microbiology
Fungi isolation & purification
Humans
Intestines microbiology
Probiotics therapeutic use
Skin microbiology
Symbiosis
T-Lymphocyte Subsets immunology
Tissue Transplantation methods
Arthritis, Psoriatic microbiology
Microbiota immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1534-6307
- Volume :
- 16
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Current rheumatology reports
- Publication Type :
- Academic Journal
- Accession number :
- 24474190
- Full Text :
- https://doi.org/10.1007/s11926-013-0407-2