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Genotoxic and hematological effects in children exposed to a chemical mixture in a petrochemical area in Mexico.
- Source :
-
Archives of environmental contamination and toxicology [Arch Environ Contam Toxicol] 2014 Jul; Vol. 67 (1), pp. 1-8. Date of Electronic Publication: 2014 Jan 29. - Publication Year :
- 2014
-
Abstract
- Children living in Coatzacoalcos, Veracruz, and in nearby surrounding areas are exposed to a mixture of pollutants from different sources. Previous studies in the area have reported genotoxic and haematotoxic compounds, such as lead (Pb), benzene, toluene, and polycyclic aromatic hydrocarbons (PAHs), in environmental and biological samples. The final toxic effects of these compounds are unknown because the toxic behaviour of each compound is modified when in a complex mixture. This is the first study on the exposure and effect of chemical mixtures on children who live near a petrochemical area. The aim of this study was to evaluate genotoxicity and haematological effects in children environmentally exposed to such mixtures and to determine whether the final effect was modified by the composition of the mixture composition. Biomarkers of exposure to Pb, benzene, toluene, and PAHs were quantified in urine and blood samples of 102 children. DNA damage was evaluated using comet assay, and haematological parameters were determined. Our results show that Pb and toluene did not surpass the exposure guidelines; the exposure was similar in all three localities (Allenede, Mundo Nuevo, and López Mateos). In contrast, exposure to PAHs was observed at three levels of exposure: low, medium, and high. The most severe effects of these mixtures were strictly related to coexposure to high levels of PAHs.
- Subjects :
- Air Pollutants analysis
Air Pollutants toxicity
Air Pollution statistics & numerical data
Benzene analysis
Benzene metabolism
Benzene toxicity
Biomarkers metabolism
Chemical Industry statistics & numerical data
Child
DNA Damage
Female
Humans
Lead analysis
Lead metabolism
Lead toxicity
Male
Mexico
Polycyclic Aromatic Hydrocarbons analysis
Polycyclic Aromatic Hydrocarbons metabolism
Polycyclic Aromatic Hydrocarbons toxicity
Toluene analysis
Toluene metabolism
Toluene toxicity
Air Pollutants metabolism
Environmental Exposure statistics & numerical data
Subjects
Details
- Language :
- English
- ISSN :
- 1432-0703
- Volume :
- 67
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Archives of environmental contamination and toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 24473790
- Full Text :
- https://doi.org/10.1007/s00244-014-9999-4