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Prognostic impact of p16 and p53 expression in oropharyngeal squamous cell carcinomas.
- Source :
-
Japanese journal of clinical oncology [Jpn J Clin Oncol] 2014 Mar; Vol. 44 (3), pp. 232-40. Date of Electronic Publication: 2014 Jan 26. - Publication Year :
- 2014
-
Abstract
- Backgrounds: A p16 protein is known to be overexpressed in human papillomavirus-positive head and neck squamous cell carcinoma specimens. p53 is a tumor suppressor protein detectable by immunohistochemistry in carcinogen-associated head and neck squamous cell carcinoma as a result of gene mutations. The purpose of this study is to investigate the prognostic impact of p16 and p53 expression in oropharyngeal squamous cell carcinomas.<br />Methods: We retrospectively examined the relationship between prognosis, and p16 and p53 expression levels of oropharyngeal squamous cell carcinoma specimens in 53 patients using immunohistochemistry.<br />Results: Overall, 55% of patients were p16 positive and 45% p16 negative, while 28% were p53 positive and 72% p53 negative. The p16 status showed an inverse relationship with the p53 status. A survival analysis by p16 status, p53 status, Union for International Cancer Control stage and main treatment modality demonstrated that only p16 status was related to better prognosis in terms of overall survival and disease-specific survival (3-year overall survival, 87 vs. 62%, P = 0.02; 3-year disease-specific survival, 90 vs. 62%, P = 0.02). To evaluate the practical prognostic factors in oropharyngeal squamous cell carcinoma patients, we classified patients as either p16-positive or p53-negative oropharyngeal squamous cell carcinomas, representing human papillomavirus-related oropharyngeal squamous cell carcinoma with wild-type p53 or the remaining patients with p16-negative or p53-positive OPSCCs, respectively. The former group showed survival advantages in terms of overall survival and disease-specific survival by log-tank test compared with the latter group (3-year overall survival, 96 vs. 58%, P = 0.005; 3-year disease-specific survival, 96 vs. 63%, P = 0.02).<br />Conclusions: A group of patients who were p16 positive/p53 negative had better prognoses in terms of overall survival and disease-specific survival than that who were p16-positive alone.
- Subjects :
- Adult
Aged
Carcinoma, Squamous Cell mortality
Carcinoma, Squamous Cell pathology
Carcinoma, Squamous Cell therapy
DNA, Viral isolation & purification
Female
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Male
Middle Aged
Neoplasm Proteins analysis
Neoplasm Staging
Oropharyngeal Neoplasms mortality
Oropharyngeal Neoplasms pathology
Oropharyngeal Neoplasms therapy
Papillomaviridae genetics
Predictive Value of Tests
Prognosis
Retrospective Studies
Carcinoma, Squamous Cell chemistry
Cyclin-Dependent Kinase Inhibitor p16 analysis
Oropharyngeal Neoplasms chemistry
Papillomaviridae isolation & purification
Tumor Suppressor Protein p53 analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1465-3621
- Volume :
- 44
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Japanese journal of clinical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 24470584
- Full Text :
- https://doi.org/10.1093/jjco/hyt223