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Nitrite induces the extravasation of iron oxide nanoparticles in hypoxic tumor tissue.
- Source :
-
NMR in biomedicine [NMR Biomed] 2014 Apr; Vol. 27 (4), pp. 425-30. Date of Electronic Publication: 2014 Jan 28. - Publication Year :
- 2014
-
Abstract
- Nitrite undergoes reconversion to nitric oxide under conditions characteristic of the tumor microenvironment, such as hypoxia and low pH. This selective conversion of nitrite into nitric oxide in tumor tissue has led to the possibility of using nitrite to enhance drug delivery and the radiation response. In this work, we propose to serially characterize the vascular response of brain tumor-bearing rats to nitrite using contrast-enhanced R2 * mapping. Imaging is performed using a multi-echo gradient echo sequence at baseline, post iron oxide nanoparticle injection and post-nitrite injection, whilst the animal is breathing air. The results indicate that nitrite sufficiently increases the vascular permeability in C6 gliomas, such that the iron oxide nanoparticles accumulate within the tumor tissue. When animals breathed 100% oxygen, the contrast agent remained within the vasculature, indicating that the conversion of nitrite to nitric oxide occurs in the presence of hypoxia within the tumor. The hypoxia-dependent, nitrite-induced extravasation of iron oxide nanoparticles observed herein has implications for the enhancement of conventional and nanotherapeutic drug delivery.<br /> (Copyright © 2014 John Wiley & Sons, Ltd.)
- Subjects :
- Animals
Brain Neoplasms blood supply
Brain Neoplasms pathology
Cell Hypoxia
Cell Line, Tumor
Misonidazole analogs & derivatives
Positron-Emission Tomography
Rats
Rats, Wistar
Time Factors
Brain Neoplasms metabolism
Extravasation of Diagnostic and Therapeutic Materials pathology
Ferric Compounds metabolism
Nanoparticles chemistry
Nitrites adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1099-1492
- Volume :
- 27
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- NMR in biomedicine
- Publication Type :
- Academic Journal
- Accession number :
- 24470164
- Full Text :
- https://doi.org/10.1002/nbm.3078