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Does gender influence the impact of impaired renal function on prognosis after ST-segment elevated myocardial infarction?
- Source :
-
Cardiology journal [Cardiol J] 2013; Vol. 20 (5), pp. 526-32. - Publication Year :
- 2013
-
Abstract
- Background: A limited number of studies have investigated the impact of gender on renal function and clinical outcomes after ST-segment elevated myocardial infarction (STEMI), and these studies have provided discrepant results.<br />Methods and Results: This study was based on a retrospective cohort, the Korean Acute Myocardial Infarction Registry (KAMIR). Patients (n = 7,679) with a discharge diagnosis of STEMI were analyzed to investigate association of gender with renal function and clinical outcomes. Compared to men, women were older and exhibited more comorbidity, including impaired renal function. Women showed higher mortality compared to men (1-month mortality,5.6% in men vs. 12.6% in women, p < 0.001; 1-year mortality, 6.8% in men vs. 14.4% in women, p < 0.001). The risk of death proportionally increased as estimated glomerular filtration rate (eGFR) decreased in both genders. After adjusting for potential confounders, hazard ratios for women did not significantly differ from those for men at each eGFR level.The interaction test showed no significant interaction between gender and eGFR in 1-month mortality and 1-year mortality.<br />Conclusions: Impaired renal function was an independent prognostic factor after STEMI in both genders, and the impact of impaired renal function on prognosis after STEMI did not significantly differ between genders.
- Subjects :
- Aged
Comorbidity
Confounding Factors, Epidemiologic
Female
Glomerular Filtration Rate
Humans
Kaplan-Meier Estimate
Kidney Diseases diagnosis
Kidney Diseases mortality
Kidney Diseases physiopathology
Male
Middle Aged
Myocardial Infarction diagnosis
Myocardial Infarction mortality
Myocardial Infarction therapy
Prognosis
Registries
Republic of Korea
Retrospective Studies
Risk Factors
Sex Factors
Time Factors
Kidney physiopathology
Kidney Diseases complications
Myocardial Infarction complications
Subjects
Details
- Language :
- English
- ISSN :
- 1898-018X
- Volume :
- 20
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Cardiology journal
- Publication Type :
- Academic Journal
- Accession number :
- 24469877
- Full Text :
- https://doi.org/10.5603/CJ.2013.0138