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Risk factors and treatment outcomes of new contralateral upper urinary urothelial carcinoma after nephroureterectomy: the experiences of a large Chinese center.
- Source :
-
Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2014 Mar; Vol. 140 (3), pp. 477-85. Date of Electronic Publication: 2014 Jan 28. - Publication Year :
- 2014
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Abstract
- Objective: To explore the risk factors and treatment outcomes of contralateral new upper tract urothelial carcinoma (UTUC) after nephroureterectomy in a large single-center cohort of UTUC patients.<br />Methods: A retrospective analysis of the clinicopathological data of 509 consecutive patients treated by nephroureterectomy from 2000 to 2010 at a high-volume center in China was conducted.<br />Results: Thirty-five patients (6.9%) were found to develop contralateral UTUC. Gross hematuria was a common symptom, and aristolochic acid (AA) containing Chinese herbs was identified as an underlying cause. In multivariate analysis, renal transplant recipients (HR = 16.507) and preoperative renal insufficiency (HR = 2.523) were independent risk factors. No correlation was found in the clinical and pathological characteristics of primary and subsequent contralateral UTUC. A second round of nephroureterectomy should be performed on renal transplant patients, whereas patients who are older, exhibit relatively better renal function, and have tumors that are single, located in the ureter and small size could be treated with nephron-sparing surgery. No survival difference was detected between the two treatment groups, and developing contralateral UTUC was not associated with worse survival.<br />Conclusion: Contralateral UTUC is comparatively rare, and gross hematuria is a common symptom. Renal transplant history and renal insufficiency are independent risk factors, and prophylactic contralateral nephroureterectomy is considered for uremic UTUC patients with proper renal replacement treatment or renal transplant recipients. These features are likely related to the mechanisms of multifocality of UTUC, and the potential correlation with AA remains to be elucidated. Tumor characteristics and renal function are informative for the decisions concerning surgical options for contralateral UTUC.
- Subjects :
- Aged
Carcinoma, Transitional Cell mortality
Carcinoma, Transitional Cell pathology
China
Female
Humans
Kaplan-Meier Estimate
Kidney Neoplasms mortality
Kidney Neoplasms pathology
Kidney Transplantation
Male
Middle Aged
Neoplasm Recurrence, Local mortality
Neoplasm Recurrence, Local prevention & control
Neoplasm Recurrence, Local surgery
Neoplasm Staging
Retrospective Studies
Risk Factors
Treatment Outcome
Ureter pathology
Urologic Neoplasms chemically induced
Urologic Neoplasms surgery
Aristolochic Acids adverse effects
Carcinogens
Carcinoma, Transitional Cell chemically induced
Carcinoma, Transitional Cell surgery
Kidney Neoplasms chemically induced
Kidney Neoplasms surgery
Nephrectomy
Ureter surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1432-1335
- Volume :
- 140
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of cancer research and clinical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 24469253
- Full Text :
- https://doi.org/10.1007/s00432-014-1585-7