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Aripiprazole effects on self-administration and pharmacodynamics of intravenous cocaine and cigarette smoking in humans.
- Source :
-
Experimental and clinical psychopharmacology [Exp Clin Psychopharmacol] 2014 Jun; Vol. 22 (3), pp. 238-47. Date of Electronic Publication: 2014 Jan 27. - Publication Year :
- 2014
-
Abstract
- Aripiprazole is a partial agonist at dopamine (D2) and serotonin (5-HT1a) receptors and 5-HT2 antagonist. Because cocaine affects dopamine and serotonin, this study assessed whether aripiprazole could diminish the reinforcing efficacy of cocaine. Secondary aims evaluated aripiprazole on ad lib cigarette smoking and with a novel 40-hr smoking abstinence procedure. Adults with regular cocaine and cigarette use completed this inpatient double blind, randomized, placebo-controlled mixed-design study. A placebo lead-in was followed by randomization to aripiprazole (0, 2 or 10 mg/day/p.o.; n = 7 completed/group). Three sets of test sessions, each consisting of 3 cocaine sample-choice (i.e., self-administration) sessions and 1 dose-response session, were conducted (once during the lead-in and twice after randomization). Sample sessions tested each cocaine dose (0, 20 and 40 mg/70 kg, i.v.) in random order; subjective, observer-rated and physiologic outcomes were collected. Later that day, participants chose between the morning's sample dose or descending amounts of money over 7 trials. In dose response sessions, all doses were given 1 hr apart in ascending order for pharmacodynamic and pharmacokinetic assessment. Two sets of smoking topography sessions were conducted during the lead-in and after randomization; 1 with and 1 without 40 hr of smoking abstinence. Number of ad lib cigarettes smoked during non-session days was collected. Cocaine produced prototypic effects, but aripiprazole did not significantly alter these effects or smoking outcomes. The smoking abstinence procedure reliably produced nicotine withdrawal and craving and increased smoking modestly. These data do not support further investigation of aripiprazole for cocaine or tobacco use disorder treatment.<br /> (PsycINFO Database Record (c) 2014 APA, all rights reserved.)
- Subjects :
- Adult
Aripiprazole
Cocaine pharmacokinetics
Cocaine-Related Disorders diagnosis
Cocaine-Related Disorders metabolism
Dose-Response Relationship, Drug
Double-Blind Method
Female
Humans
Injections, Intravenous
Male
Piperazines pharmacokinetics
Quinolones pharmacokinetics
Self Administration
Smoking metabolism
Treatment Outcome
Cocaine administration & dosage
Cocaine-Related Disorders drug therapy
Piperazines therapeutic use
Quinolones therapeutic use
Self Report
Smoking drug therapy
Smoking Cessation methods
Subjects
Details
- Language :
- English
- ISSN :
- 1936-2293
- Volume :
- 22
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Experimental and clinical psychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 24467369
- Full Text :
- https://doi.org/10.1037/a0035165