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The seroepidemiology of Haemophilus influenzae type b prior to introduction of an immunization programme in Kathmandu, Nepal.
- Source :
-
PloS one [PLoS One] 2014 Jan 22; Vol. 9 (1), pp. e85055. Date of Electronic Publication: 2014 Jan 22 (Print Publication: 2014). - Publication Year :
- 2014
-
Abstract
- Haemophilus influenzae type b (Hib) is now recognized as an important pathogen in Asia. To evaluate disease susceptibility, and as a marker of Hib transmission before routine immunization was introduced in Kathmandu, 71 participants aged 7 months-77 years were recruited and 15 cord blood samples were collected for analysis of anti-polyribosylribitol phosphate antibody levels by enzyme-linked immunosorbent assay. Only 20% of children under 5 years old had levels considered protective (>0.15 µg/ml), rising to 83% of 15-54 year-olds. Prior to introduction of Hib vaccine in Kathmandu, the majority of young children were susceptible to disease.
- Subjects :
- Adolescent
Adult
Aged
Antibodies, Bacterial blood
Antibodies, Bacterial immunology
Child
Child, Preschool
Enzyme-Linked Immunosorbent Assay
Haemophilus Infections epidemiology
Haemophilus Infections microbiology
Haemophilus influenzae type b physiology
Host-Pathogen Interactions immunology
Humans
Infant
Middle Aged
Nepal epidemiology
Polysaccharides immunology
Polysaccharides, Bacterial immunology
Seroepidemiologic Studies
Vaccination methods
Young Adult
Bacterial Capsules immunology
Haemophilus Infections immunology
Haemophilus Vaccines immunology
Haemophilus influenzae type b immunology
Immunization Programs methods
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 9
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 24465475
- Full Text :
- https://doi.org/10.1371/journal.pone.0085055