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Administering 25-hydroxyvitamin D3 in vitamin D-deficient young type 1A diabetic patients reduces reactivity against islet autoantigens.
- Source :
-
Clinical nutrition (Edinburgh, Scotland) [Clin Nutr] 2014 Dec; Vol. 33 (6), pp. 1153-6. Date of Electronic Publication: 2014 Jan 09. - Publication Year :
- 2014
-
Abstract
- Background & Aims: We investigated whether improving 25-hydroxyvitamin D status in young type 1A diabetic patients reduces reactivity of peripheral blood mononuclear cells against islet autoantigens and associates with beta-cell functional changes.<br />Methods: Eight patients with 25-hydroxyvitamin D deficiency (<20 ng/ml), out of 15 consecutive young type 1A diabetic subjects received 25-hydroxyvitamin D3 to achieve and maintain levels above 50 ng/ml for up to one year. Peripheral blood mononuclear cell reactivity (Interferon-γ spots) against beta-cell autoantigens (glutamic acid decarboxylase 65-kD isoform, proinsulin and tyrosine phosphatase-like protein IA-2) and C-peptide during mixed meal were assessed before and after 25-hydroxyvitamin D3 replenishment.<br />Results: Target 25-hydroxyvitamin D blood levels were safely reached and maintained. Peripheral blood mononuclear cell reactivity against glutamic acid decarboxylase 65-kD isoform (3.8 ± 4.0 vs. 45 ± 16) and proinsulin (3.5 ± 3.2 vs. 75 ± 51) decreased significantly (p < 0.001 and p < 0.02) upon 25-hydroxyvitamin D3 replenishment, which was correlated with 25-hydroxyvitamin D concentrations. C-peptide values remained stable after one year of treatment.<br />Conclusions: Safely restored and maintained 25-hydroxyvitamin D levels associated with reduced peripheral blood mononuclear cell reactivity against beta-cell autoantigens with no significant decrease of beta-cell function in this cohort of patients.<br /> (Copyright © 2014 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.)
- Subjects :
- Adolescent
C-Peptide metabolism
Calcifediol blood
Child
Diabetes Mellitus, Type 1 blood
Female
Glutamate Decarboxylase metabolism
Humans
Insulin-Secreting Cells drug effects
Insulin-Secreting Cells metabolism
Interferon-gamma metabolism
Leukocytes, Mononuclear drug effects
Leukocytes, Mononuclear metabolism
Male
Proinsulin metabolism
Vitamin D Deficiency blood
Autoantigens metabolism
Calcifediol administration & dosage
Diabetes Mellitus, Type 1 drug therapy
Vitamin D Deficiency drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1532-1983
- Volume :
- 33
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Clinical nutrition (Edinburgh, Scotland)
- Publication Type :
- Academic Journal
- Accession number :
- 24461876
- Full Text :
- https://doi.org/10.1016/j.clnu.2014.01.001