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Benzimidazole CB2 agonists: design, synthesis and SAR.

Authors :
Nanda KK
Henze DA
Della Penna K
Desai R
Leitl M
Lemaire W
White RB
Yeh S
Brouillette JN
Hartman GD
Bilodeau MT
Trotter BW
Source :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2014 Feb 15; Vol. 24 (4), pp. 1218-21. Date of Electronic Publication: 2013 Dec 25.
Publication Year :
2014

Abstract

A new series of CB2-selective agonists containing a benzimidazole core is reported. Design, synthesis, SAR and pharmacokinetic data for selected compounds are described.<br /> (Copyright © 2013 Elsevier Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1464-3405
Volume :
24
Issue :
4
Database :
MEDLINE
Journal :
Bioorganic & medicinal chemistry letters
Publication Type :
Academic Journal
Accession number :
24461289
Full Text :
https://doi.org/10.1016/j.bmcl.2013.12.068