Significance of higher-order chromatin architecture for neuronal function and dysfunction.

Authors :: Wilczynski GM
Source :: Neuropharmacology [Neuropharmacology] 2014 May; Vol. 80, pp. 28-33. Date of Electronic Publication: 2014 Jan 20.
Publication Year :: 2014
Abstract: Recent studies in neurons indicate that the large-scale chromatin architectural framework, including chromosome territories or lamina-associated chromatin, undergoes dynamic changes that represent an emergent level of regulation of neuronal gene-expression. This phenomenon has been implicated in neuronal differentiation, long-term potentiation, seizures, and disorders of neural plasticity such as Rett syndrome and epilepsy.<br /> (Copyright © 2014 Elsevier Ltd. All rights reserved.)

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