Back to Search
Start Over
Effects of topiroxostat on the serum urate levels and urinary albumin excretion in hyperuricemic stage 3 chronic kidney disease patients with or without gout.
- Source :
-
Clinical and experimental nephrology [Clin Exp Nephrol] 2014 Dec; Vol. 18 (6), pp. 876-84. Date of Electronic Publication: 2014 Jan 22. - Publication Year :
- 2014
-
Abstract
- Background: Topiroxostat, a selective xanthine oxidase inhibitor, shows effective reduction in the serum urate level in hyperuricemic patients with or without gout. The objective of this study was to evaluate the efficacy and safety of topiroxostat in hyperuricemic stage 3 chronic kidney disease patients with or without gout.<br />Methods: The study design was a 22-week, randomized, multicenter, double-blind study. The enrolled patients were randomly assigned to treatment with topiroxostat 160 mg/day (n = 62) or to the placebo (n = 61). The endpoints were the percent change in the serum urate level, change in the estimated glomerular filtration rate, the urinary albumin-to-creatinine ratio, the proportion of patients with serum urate levels of 356.88 μmol/L or less, blood pressure, and serum adiponectin.<br />Results: After 22 weeks, although the changes in the estimated glomerular filtration rate and blood pressure were not significant, the percent change in the serum urate level (-45.38 vs. -0.08 %, P < 0.0001) and the percent change in urinary albumin-to-creatinine ratio (-33.0 vs. -6.0 %, P = 0.0092) were found to have decreased in the topiroxostat as compared with the placebo. Although the incidence of 'alanine aminotransferase increased' was higher in the topiroxostat, serious adverse event rates were similar in the two groups.<br />Conclusion: Topiroxostat 160 mg effectively reduced the serum urate level in the hyperuricemic stage 3 chronic kidney disease patients with or without gout.
- Subjects :
- Adiponectin blood
Aged
Albuminuria blood
Albuminuria epidemiology
Blood Pressure drug effects
Comorbidity
Creatinine urine
Double-Blind Method
Enzyme Inhibitors pharmacology
Female
Glomerular Filtration Rate drug effects
Gout blood
Gout epidemiology
Humans
Hyperuricemia blood
Hyperuricemia epidemiology
Male
Middle Aged
Nitriles pharmacology
Nitriles therapeutic use
Prevalence
Pyridines pharmacology
Pyridines therapeutic use
Renal Insufficiency, Chronic blood
Renal Insufficiency, Chronic epidemiology
Treatment Outcome
Albuminuria prevention & control
Enzyme Inhibitors therapeutic use
Gout drug therapy
Hyperuricemia drug therapy
Renal Insufficiency, Chronic drug therapy
Uric Acid blood
Xanthine Oxidase antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 1437-7799
- Volume :
- 18
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Clinical and experimental nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 24448692
- Full Text :
- https://doi.org/10.1007/s10157-014-0935-8