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Fungal endophthalmitis associated with compounded products.
- Source :
-
Emerging infectious diseases [Emerg Infect Dis] 2014 Feb; Vol. 20 (2), pp. 248-56. - Publication Year :
- 2014
-
Abstract
- Fungal endophthalmitis is a rare but serious infection. In March 2012, several cases of probable and laboratory-confirmed fungal endophthalmitis occurring after invasive ocular procedures were reported nationwide. We identified 47 cases in 9 states: 21 patients had been exposed to the intraocular dye Brilliant Blue G (BBG) during retinal surgery, and the other 26 had received an intravitreal injection containing triamcinolone acetonide. Both drugs were produced by Franck's Compounding Lab (Ocala, FL, USA). Fusarium incarnatum-equiseti species complex mold was identified in specimens from BBG-exposed case-patients and an unopened BBG vial. Bipolaris hawaiiensis mold was identified in specimens from triamcinolone-exposed case-patients. Exposure to either product was the only factor associated with case status. Of 40 case-patients for whom data were available, 39 (98%) lost vision. These concurrent outbreaks, associated with 1 compounding pharmacy, resulted in a product recall. Ensuring safety and integrity of compounded medications is critical for preventing further outbreaks associated with compounded products.
- Subjects :
- Aged
Aged, 80 and over
Blindness epidemiology
Blindness etiology
Blindness surgery
Drug Recalls
Endophthalmitis epidemiology
Endophthalmitis etiology
Endophthalmitis surgery
Eye Infections, Fungal epidemiology
Eye Infections, Fungal etiology
Eye Infections, Fungal surgery
Female
Fusarium pathogenicity
Fusarium physiology
Humans
Male
Middle Aged
Retina microbiology
Retina pathology
Retina surgery
Saccharomycetales pathogenicity
Saccharomycetales physiology
United States epidemiology
Vitreous Body microbiology
Vitreous Body pathology
Vitreous Body surgery
Blindness microbiology
Endophthalmitis microbiology
Eye Infections, Fungal microbiology
Ophthalmic Solutions adverse effects
Rosaniline Dyes adverse effects
Triamcinolone Acetonide adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1080-6059
- Volume :
- 20
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Emerging infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 24447640
- Full Text :
- https://doi.org/10.3201/eid2002.131257