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A simple model of NF-κB dynamics reproduces experimental observations.
- Source :
-
Journal of theoretical biology [J Theor Biol] 2014 Apr 21; Vol. 347, pp. 44-53. Date of Electronic Publication: 2014 Jan 18. - Publication Year :
- 2014
-
Abstract
- The mathematical modeling of the NF-κB oscillations has attracted considerable attention in recent times, but there is a lack of simple models in the literature that can capture the main features of the dynamics of this important transcription factor. For this reason we propose a simple model that summarizes the key steps of the NF-κB pathway. We show that the resulting 5-dimensional dynamical system can reproduce different phenomena observed in experiments. Our model can display smooth and spiky oscillations in the amount of nuclear NF-κB and can reproduce the variety of dynamics observed when different stimulations such as TNF-α and LPS are used. Furthermore we show that the model can be easily extended to reproduce the expression of early, intermediate and late genes upon stimulation. As a final example we show that our simple model can mimic the different transcriptional outputs observed when cells are treated with two different drugs leading to nuclear localization of NF-κB: Leptomycin B and Cycloheximide.<br /> (Copyright © 2014 Elsevier Ltd. All rights reserved.)
- Subjects :
- Transcription, Genetic
Models, Theoretical
NF-kappa B metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1095-8541
- Volume :
- 347
- Database :
- MEDLINE
- Journal :
- Journal of theoretical biology
- Publication Type :
- Academic Journal
- Accession number :
- 24447586
- Full Text :
- https://doi.org/10.1016/j.jtbi.2014.01.015